benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate

Base Information

• Chemical Name: benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate
• CAS No.: 1044253-28-2
• Molecular Formula: C₄₂H₄₄N₂O₇
• Molecular Weight: 688.821
• Mol file: 1044253-28-2.mol

Synonyms:benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate

Chemical Property of benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate

There total 1 articles about benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl 4-{3-methoxy-4-[(prop-2-ynylamino)methyl]phenoxy}butanoate (1044253-24-8) + Fmoc-Val-OH (68858-20-8) → benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate (1044253-28-2)

Guidance literature:

Fmoc-Val-OH; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.333333h;

benzyl 4-{3-methoxy-4-[(prop-2-ynylamino)methyl]phenoxy}butanoate; In dichloromethane; at 20 ℃;

DOI:10.1002/ejoc.200800143

Reference yield:

benzyl 4-(4-{[{(2S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-3-methylbutanoyl}(prop-2-ynyl)amino]methyl}-3-methoxyphenox)butanoate (1044253-28-2) → C27H34N2O5

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200800143

upstream raw materials:

benzyl 4-{3-methoxy-4-[(prop-2-ynylamino)methyl]phenoxy}butanoate

Fmoc-Val-OH