C₆₃H₇₀N₁₀O₁₁

Base Information

• Chemical Name: C₆₃H₇₀N₁₀O₁₁
• CAS No.: 84636-31-7
• Molecular Formula: C₆₃H₇₀N₁₀O₁₁
• Molecular Weight: 1143.31
• Mol file: 84636-31-7.mol

Synonyms:C₆₃H₇₀N₁₀O₁₁

Chemical Property of C₆₃H₇₀N₁₀O₁₁

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₃H₇₀N₁₀O₁₁

There total 7 articles about C₆₃H₇₀N₁₀O₁₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl (84636-30-6) + 35925-21-4 → C63H70N10O11 (84636-31-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 20h; Yield given;

DOI:10.1021/jm00138a009

Reference yield:

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) → C63H70N10O11 (84636-31-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 90 percent / TEA, dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 16 h

2: 4 M HCl / ethyl acetate / 0.33 h

3: 91 percent / TEA, dicycloxexylcarbodiimide (DCC), 1-hydroxybenzotriazole (HBT) / CH₂Cl₂ / 16 h / 0 °C

4: 4 N KOH / methanol / 0.83 h / 0 °C

5: 76 percent / 1-hydroxybenzotriazole (HBT), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 16 h / 0 °C

6: 50percent F₃AcOH / CH₂Cl₂ / 0.25 h / Ambient temperature

7: 1-hydroxybenzotriazole (HBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 20 h / 0 °C

With hydrogenchloride; potassium hydroxide; TEA; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00138a009

Reference yield:

Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH (50715-57-6) → C63H70N10O11 (84636-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / 1-hydroxybenzotriazole (HBT), dicyclohexylcarbodiimide (DCC) / CH₂Cl₂ / 16 h / 0 °C

2: 50percent F₃AcOH / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 1-hydroxybenzotriazole (HBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 20 h / 0 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00138a009

upstream raw materials:

Ser(Bzl)-Tyr(Bzl)-Gly-Leu-OBzl

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

Boc-Ser(Bzl)-Tyr(Bzl)-Glu-OH

Downstream raw materials:

pGlu-His-Trp-Ser-Tyr-Gly-Leu