N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane

Base Information

• Chemical Name: N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane
• CAS No.: 80958-67-4
• Molecular Formula: C₃₃H₄₃N₃O₆S₂
• Molecular Weight: 641.853

Synonyms:N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane

Chemical Property of N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane

There total 3 articles about N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N1,N8-di(p-toluenesulfonyl)-1,8-diaminooctane (83492-49-3) + 5'-Deoxy-2',5'-dichloro-3,4'-O-isopropylidenepyridoxine Hydrochloride (80958-57-2) → N2,N11-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane (80958-67-4)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 2.5h;

DOI:10.1021/jo00156a027

Reference yield: 76.0%

5'-Deoxy-2',5'-dichloro-3,4'-O-isopropylidenepyridoxine Hydrochloride (80958-57-2) + C22H30N2O4S2(2-)*2Na(1+) (80958-61-8) → N2,N11-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane (80958-67-4)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.1246/cl.1981.1749

Reference yield:

2'-hydroxy-3,4'-O-isopropylidene-pyridoxine (49797-82-2) → N2,N11-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane (80958-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / benzene / Ambient temperature

2: 76 percent / dimethylformamide / 3 h / 90 °C

With thionyl chloride; In N,N-dimethyl-formamide; benzene;

DOI:10.1246/cl.1981.1749

upstream raw materials:

N¹,N⁸-di(p-toluenesulfonyl)-1,8-diaminooctane

5'-Deoxy-2',5'-dichloro-3,4'-O-isopropylidenepyridoxine Hydrochloride

C₂₂H₃₀N₂O₄S₂^(2-)*2Na⁽¹⁺⁾

2'-hydroxy-3,4'-O-isopropylidene-pyridoxine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 80958-67-4 N²,N¹¹-di-p-toluenesulfonyl-17-hydroxy-18-hydroxymethyl-17,18'-O-isopropylidene-2,11-diaza<12>(2,5)pyridinophane

Send

Send

Metric Ton KG G Pound L ML

Send

Send