4'-Hydroxy-2-iod-3'-methoxyacetophenon

Base Information

• Chemical Name: 4'-Hydroxy-2-iod-3'-methoxyacetophenon
• CAS No.: 105174-52-5
• Molecular Formula: C₉H₉IO₃
• Molecular Weight: 292.073
• Mol file: 105174-52-5.mol

Synonyms:4'-Hydroxy-2-iod-3'-methoxyacetophenon

Chemical Property of 4'-Hydroxy-2-iod-3'-methoxyacetophenon

Chemical Property:

• Melting Point: 103°C

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-Hydroxy-2-iod-3'-methoxyacetophenon

There total 2 articles about 4'-Hydroxy-2-iod-3'-methoxyacetophenon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 4'-Hydroxy-2-iod-3'-methoxyacetophenon (105174-52-5)

Guidance literature:

With ammonium nitrate; sulfuric acid; iodine; In water; acetonitrile; at 60 ℃; for 25h; regioselective reaction;

DOI:10.1016/j.tetlet.2014.08.055

Reference yield: 52.0%

α-bromo-3-methoxy-4-hydroxyacetophenone (69638-06-8) → 4'-Hydroxy-2-iod-3'-methoxyacetophenon (105174-52-5)

Guidance literature:

With sodium iodide; In acetone; for 1h; Ambient temperature; var. ω-halogeno ketones; var. times;

upstream raw materials:

α-bromo-3-methoxy-4-hydroxyacetophenone

1-(3-methoxy-4-hydroxyphenyl)ethanone