N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide
CAS No.:1433906-38-7
Molecular Formula:C₂₀H₁₈ClF₃N₂O
Molecular Weight:394.824
Hs Code.:

Synonyms:N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

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Chemical Property of N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

There total 5 articles about N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1065010-87-8
potassium cyclopropyltrifluoroborate

: 1433906-34-3
N-[[1-(5-bromo-3-chloro-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

: 1433906-38-7
N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; toluene; at 100 - 130 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1227515-31-2
2-(5-bromo-3-chloropyridine-2-yl)acetonitrile

: 1433906-38-7
N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 2.5 h / 20 - 60 °C

2: diisobutylaluminium hydride / dichloromethane / 25 h / -78 - 40 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 1 h / 100 - 130 °C / Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-benzyl-N,N,N-triethylammonium chloride; diisobutylaluminium hydride; caesium carbonate; triethylamine; sodium hydroxide; In dichloromethane; water; toluene;

Reference yield:

: 97966-00-2
5-bromo-2,3-dichloropyridine

: 1433906-38-7
N-[[1-(3-chloro-5-cyclopropyl-2-pyridyl)cyclopropyl]methyl]-2-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 - 35 °C / Inert atmosphere

2: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 2.5 h / 20 - 60 °C

3: diisobutylaluminium hydride / dichloromethane / 25 h / -78 - 40 °C

4: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 1 h / 100 - 130 °C / Microwave irradiation; Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-benzyl-N,N,N-triethylammonium chloride; diisobutylaluminium hydride; caesium carbonate; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; toluene;