tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate
CAS No.:1233856-28-4
Molecular Formula:C₂₈H₃₄N₄O₄
Molecular Weight:490.602
Hs Code.:

Synonyms:tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 146698-61-5
4-(4-(benzyloxy)phenyl)-1H-imidazole

: tert-butyl 4-(chlorocarbonyl(methyl)amino)piperidine-1-carboxylate

: 1233856-28-4
tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

Guidance literature:: 4-(4-(benzyloxy)phenyl)-1H-imidazole; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.25h;

tert-butyl 4-(chlorocarbonyl(methyl)amino)piperidine-1-carboxylate; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 99-93-4
4-Hydroxyacetophenone

: 1233856-28-4
tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 18 h / Reflux

2.1: phenyltrimethylammonium tribromide / tetrahydrofuran / 0 °C

3.1: water / 7 h / 140 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

4.2: 1 h / 20 °C

With phenyltrimethylammonium tribromide; sodium hydride; potassium carbonate; In tetrahydrofuran; water; acetone; mineral oil;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1233856-28-4
tert-butyl 4-(4-(4-(benzyloxy)phenyl)-N-methyl-1H-imidazole-1-carboxamido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / water; methanol / 2 h / 50 °C / 15001.5 Torr / Inert atmosphere; Autoclave

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h

3.2: 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; mineral oil;