3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

Base Information

Chemical Name:3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran
CAS No.:946126-67-6
Molecular Formula:C₂₄H₁₇FN₂O₃S
Molecular Weight:432.475
Hs Code.:

Synonyms:3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

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Chemical Property of 3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

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Technology Process of 3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

There total 11 articles about 3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 615-20-3
2-chlorobenzo[d][1,3]thiazole

: 946126-97-2
2-oxo-2H-3-(2-fluoro-3-aminobenzyl)-4-methyl-7-hydroxy-1-benzopyran

: 946126-67-6
3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 19h;

Reference yield:

: 946126-61-0
4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(thiazol-2-yloxy)-2-oxo-2H-1-benzopyran

: 946126-67-6
3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 946126-67-6
3-(2-fluoro-3-aminobenzyl)-4-methyl-7-(benzothiazol-2-yloxy)-2-oxo-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 7 steps

1.1: cesium fluoride / dimethyl sulfoxide / 0.67 h / 140 °C

2.1: diisobutylaluminium hydride / toluene / 1 h / -78 - 0 °C

2.2: 1 h / -78 - 20 °C

3.1: phosphorus tribromide / diethyl ether / 0.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 20 °C

5.1: sulfuric acid / 0 - 20 °C

6.1: tin(II) chloride hydrate / ethyl acetate / 1 h / Inert atmosphere; Reflux

7.1: caesium carbonate / N,N-dimethyl-formamide / 19 h / 100 °C

With tin(II) chloride hydrate; sulfuric acid; phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; caesium carbonate; cesium fluoride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;