(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

Base Information

Chemical Name:(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one
CAS No.:869377-57-1
Molecular Formula:C₂₈H₃₃NO₃Si
Molecular Weight:459.66
Hs Code.:

Synonyms:(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

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Chemical Property of (6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

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Technology Process of (6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

There total 8 articles about (6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 869377-56-0
(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepine-2,8-dione

: 869377-57-1
(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

: 1182278-01-8
C₂₈H₃₅NO₃Si

Guidance literature:: With aluminium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1021/jo901059n

Reference yield: 57.0%

: 869377-56-0
(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepine-2,8-dione

: 869377-57-1
(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

Guidance literature:: With aluminium hydride; In tetrahydrofuran; methanol; at 0 - 20 ℃;
DOI:10.1021/ol0522079

Reference yield:

: triisopropyl-(4-vinyl-furan-2-yloxy)-silane

: 869377-57-1
(6R,10aR,10bR)-6-tert-butyldiphenylsilyloxymethyl-9,10,10a,10b-tetrahydro-6H-furo[2,3-c]pyrrolo[1,2-a]azepin-2(8H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / BF₃*Et₂O / diethyl ether / 1.5 h / 0 °C

2: 100 percent / Grubbs catalyst / CH₂Cl₂ / 14 h / 20 °C

3: 57 percent / aluminum hydride / tetrahydrofuran; methanol / 0 - 20 °C

With aluminium hydride; boron trifluoride diethyl etherate; Grubbs catalyst first generation; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1: Mannich reaction;
DOI:10.1021/ol0522079