(R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

Base Information

Chemical Name:(R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide
CAS No.:1609247-32-6
Molecular Formula:C₁₇H₂₃N₃OS
Molecular Weight:317.455
Hs Code.:

Synonyms:(R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

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Chemical Property of (R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

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Technology Process of (R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

There total 2 articles about (R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-methyl-N-[(1-phenyl-1H-pyrazol-4-yl)methylidene]-2-propanesulfinamide

: 106-95-6
allyl bromide

: 1609247-32-6
(R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

: 1609247-46-2
(R)-2-methyl-N-[(1S)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

Guidance literature:: (R)-2-methyl-N-[(1-phenyl-1H-pyrazol-4-yl)methylidene]-2-propanesulfinamide; allyl bromide; With zinc; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; Overall yield = 98 %; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2014.03.003

Reference yield:

: 54605-72-0
1-phenyl-1H-pyrazole-4-carbaldehyde

: 1609247-32-6
(R)-2-methyl-N-[(1R)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

: 1609247-46-2
(R)-2-methyl-N-[(1S)-1-(1-phenyl-1H-pyrazol-4-yl)-3-butenyl]-2-propanesulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran / 20 h / 50 °C / Inert atmosphere

2.1: zinc / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With titanium(IV) isopropylate; zinc; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2014.03.003