2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Base Information

Chemical Name:2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate
CAS No.:1456906-91-4
Molecular Formula:C₂HF₃O₂*C₂₉H₃₃N₃O₂
Molecular Weight:569.624
Hs Code.:

Synonyms:2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

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Chemical Property of 2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

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Technology Process of 2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

There total 9 articles about 2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1456905-59-1
2-(N-benzenecarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

: 155-09-9
trans-2-phenylcyclopropylamine

: 76-05-1
trifluoroacetic acid

: 1456906-91-4
2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Guidance literature:: 2-(N-benzenecarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide; trans-2-phenylcyclopropylamine; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 11h;

trifluoroacetic acid; In acetonitrile;
DOI:10.1002/anie.201303999

Reference yield: 29.0%

: 1456905-59-1
2-(N-benzenecarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide

: 76-05-1
trifluoroacetic acid

: (±)-trans-2-phenylcyclopropylamine

: 1456906-91-4
2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Guidance literature:: 2-(N-benzenecarbonylamino)-6-(O-methanesulfonyl)-N-benzylhexanamide; (±)-trans-2-phenylcyclopropylamine; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 11h;

trifluoroacetic acid;

Reference yield:

: 2389-45-9
Boc-Lys(Z)-OH

: 1456906-91-4
2-(N-benzenecarbonylamino)-6-(trans-2-phenylcyclopropan-1-amino)-N-benzylhexanamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 13.5 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C / Cooling with ice

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 19 h / 20 °C

4: 5%-palladium/activated carbon; hydrogen / methanol; chloroform / 28.5 h / 20 °C

5: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 70 °C

6: triethylamine; dmap / dichloromethane / 1 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 11 h / 60 °C

With hydrogenchloride; dmap; 5%-palladium/activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999