Technology Process of 4-(benzyloxy)-3,5-bis(3-hydroxypropyl)-2',6'-dinitrobiphenyl
There total 11 articles about 4-(benzyloxy)-3,5-bis(3-hydroxypropyl)-2',6'-dinitrobiphenyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 87 percent / BCl3 (gas) / chlorobenzene / 2 h / 25 °C
2: 97 percent / K2CO3 / dimethylformamide / 18 h
3: 1.) 9-BBN, 2.) 3 M NaOH, 30percent H2O2 / 1.) THF, 65 deg C, 2.5 h, 2.) THF, below 28 deg C, 30 min
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; boron trichloride; potassium carbonate;
In
N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/ja00021a042
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / K2CO3 / dimethylformamide / 18 h
2: 1.) 9-BBN, 2.) 3 M NaOH, 30percent H2O2 / 1.) THF, 65 deg C, 2.5 h, 2.) THF, below 28 deg C, 30 min
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; potassium carbonate;
In
N,N-dimethyl-formamide;
DOI:10.1021/ja00021a042
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / Cu / 0.5 h / 220 °C
2: 91 percent / BBr3 / CH2Cl2 / 1.2 h / 25 °C
3: 93 percent / Na / ethanol / 24 h / 65 °C
4: 91 percent / BCl3 (gas) / chlorobenzene / 1.5 h / 25 °C
5: 85 percent / Na / ethanol / 48 h / 65 °C
6: 87 percent / BCl3 (gas) / chlorobenzene / 2 h / 25 °C
7: 97 percent / K2CO3 / dimethylformamide / 18 h
8: 1.) 9-BBN, 2.) 3 M NaOH, 30percent H2O2 / 1.) THF, 65 deg C, 2.5 h, 2.) THF, below 28 deg C, 30 min
With
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; sodium; boron trichloride; boron tribromide; copper; potassium carbonate;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;
DOI:10.1021/ja00021a042
