(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

Base Information

Chemical Name:(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone
CAS No.:1315469-16-9
Molecular Formula:C₂₄H₂₁Cl₂N₃O₃
Molecular Weight:470.355
Hs Code.:

Synonyms:(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

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Chemical Property of (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

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Technology Process of (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

There total 11 articles about (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1315468-81-5
2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoic acid methyl ester

: 1315469-16-9
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

Guidance literature:: 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoic acid methyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2.5h;

With water; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1315469-16-9
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 8 steps

1: 19 h / 20 - 30 °C

2: triethylamine / dichloromethane / 72 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 900.09 Torr

4: triphenylphosphine / N,N-dimethyl-formamide / 4 h / 135 °C

5: borane-THF / tetrahydrofuran / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 20 °C

7: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 20 h / 120 °C / 52505.3 Torr

8: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C

With lithium aluminium tetrahydride; borane-THF; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1940-42-7,79151-08-9
4-bromo-2,5-dichlorophenol

: 1315469-16-9
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxymethyl-phenoxy)-pyridin-3-yl]-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(actonitrile)copper(I) hexafluorophosphate / o-xylene / 16 h / 120 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 20 °C

3: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / ethyl acetate / 20 h / 120 °C / 52505.3 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 2.5 h / 20 °C

With lithium aluminium tetrahydride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrakis(actonitrile)copper(I) hexafluorophosphate; In tetrahydrofuran; o-xylene; ethyl acetate; N,N-dimethyl-formamide;