4-(4-Morpholinopiperidin-1-yl)aniline

Base Information

• Chemical Name: 4-(4-Morpholinopiperidin-1-yl)aniline
• CAS No.: 867291-42-7
• Molecular Formula: C₁₅H₂₃N₃O
• Molecular Weight: 261.367
• Mol file: 867291-42-7.mol

Synonyms:4-(1-(4-aminophenyl)piperidin-4-yl)morpholine

Chemical Property of 4-(4-Morpholinopiperidin-1-yl)aniline

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-(4-Morpholinopiperidin-1-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Morpholinopiperidin-1-yl)aniline

There total 7 articles about 4-(4-Morpholinopiperidin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-(1-(4-nitrophenyl)piperidin-4-yl)morpholine (867291-41-6) → 4-(1-(4-aminophenyl)piperidin-4-yl)morpholine (867291-42-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 15h; under 1706.63 Torr;

Reference yield: 40.0%

→ 4-(1-(4-aminophenyl)piperidin-4-yl)morpholine (867291-42-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-(1-(4-aminophenyl)piperidin-4-yl)morpholine (867291-42-7)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen; acetic acid / methanol

2: hydrogenchloride / 1,4-dioxane

3: potassium carbonate / N,N-dimethyl-formamide / 120 °C

4: hydrogen / methanol

With hydrogenchloride; palladium on activated charcoal; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-(morpholin-4-yl)piperidine-1-carboxylate

4-(piperidin-4-yl)morpholine dihydrochloride

4-(1-(4-nitrophenyl)piperidin-4-yl)morpholine

Refernces

• 1、 -. "CYCLIN-DEPENDENT KINASE INHIBITORS". Page/Page column 138-140. . Retrieved 2020/07/15.
• 2、 -. "CYCLIN-DEPENDENT KINASE INHIBITORS". Page/Page column 157. . Retrieved 2020/07/15.