(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

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Chemical Name:(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester
CAS No.:461720-00-3
Molecular Formula:C₄₁H₅₈N₆O₉
Molecular Weight:778.946
Hs Code.:

(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

Synonyms:(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

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Chemical Property of (2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

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Technology Process of (2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

There total 5 articles about (2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54054-85-2
1-(3-nitrophenyl)piperazine

: 461720-00-3
(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: EDCI; HOBt; i-Pr₂NEt / dimethylformamide

2: Fe; aq. NH₄Cl / ethanol

3: HgCl₂; Et₃N / dimethylformamide

With iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; mercury dichloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.02.075

Reference yield:

: 1,3-bis(tert-butoxycarbonyl)-2(1H)-tetrahydropyrimidinethione

: (2S)-5-[4-(3-aminophenyl)-piperazin-1-yl]-2-benzyloxycarbonylamino-5-oxopentanoic acid tert-butyl ester

: 461720-00-3
(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 402-67-5
3-fluoro-1-nitrobenzene

: 461720-00-3
(2S)-2-benzyloxycarbonylamino-5-[4-[3-[1,3-bis(tertbutoxycarbonyl)hexahydropyrimidin-2-ylidene]aminophenyl]piperazin-1-yl]-5-oxopentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 100 °C

2: EDCI; HOBt; i-Pr₂NEt / dimethylformamide

3: Fe; aq. NH₄Cl / ethanol

4: HgCl₂; Et₃N / dimethylformamide

With iron; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; mercury dichloride; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.02.075