(3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate
CAS No.:1333242-25-3
Molecular Formula:C₃₁H₂₇N₃O₈S
Molecular Weight:601.637
Hs Code.:

Synonyms:(3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

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Chemical Property of (3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

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Technology Process of (3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

There total 3 articles about (3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 885227-03-2
5-(2-hydroxyethoxy)-1H-indole-2-carboxylic acid

: 1333242-48-0
(5-nitro-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl 4-methylbenzenesulfonate

: 1333242-25-3
(3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

Guidance literature:: With toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; at 20 ℃;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 193225-63-7
3-(tert-butoxycarbonyl)-1-(hydroxymethyl)-5-nitro-1,2-dihydro-3H-benzindole

: 1333242-25-3
(3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

3: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 20 °C

With pyridine; hydrogenchloride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1333242-25-3
(3-(5-(2-hydroxyethoxy)-1H-indole-2-carbonyl)-5-nitro-2,3-dihydro-1H-benzo[e]indol-1yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 10 - 20 °C

3: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 20 °C

With pyridine; hydrogenchloride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2011.06.073