(2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

Base Information

Chemical Name:(2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal
CAS No.:113957-03-2
Molecular Formula:C₂₆H₄₀O₆
Molecular Weight:448.6
Hs Code.:

Synonyms:(2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

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Chemical Property of (2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

Chemical Property:

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Technology Process of (2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

There total 6 articles about (2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108470-24-2
5(S)-(5(R)-<2-(3,4-dimethoxybenzyloxy)ethyl>-2(S)-isopropyloxy-3(R)-methyl-6(S)-tetrahydropyranyl)-4(R)-hydroxy-1-hexene

: 113957-03-2
(2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 1 N HCl / tetrahydrofuran / 2 h / 50 °C

2: 100 percent / Ca(BH₄)2 / ethanol / 1.5 h / Ambient temperature

3: 84 percent / CSA / benzene / 3 h / Ambient temperature

4: 1.) (COCl)2/DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -80 deg C, 1 h; 2.) CH₂Cl₂, -80 deg C to room temp.

With hydrogenchloride; calcium borohydride; oxalyl dichloride; camphor-10-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; benzene;
DOI:10.1248/cpb.35.2219

Reference yield:

: 113919-01-0
5(R)-<5(R)-(2-hydroxyethyl)-2(S)-isopropyloxy-3(R)-methyl-6(S)-tetrahydropyranyl>-4(R)-hydroxy-1-hexane

: 113957-03-2
(2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / NaH / tetrahydrofuran; dimethylsulfoxide / 11 h / Ambient temperature

2: 95 percent / 1 N HCl / tetrahydrofuran / 2 h / 50 °C

3: 100 percent / Ca(BH₄)2 / ethanol / 1.5 h / Ambient temperature

4: 84 percent / CSA / benzene / 3 h / Ambient temperature

5: 1.) (COCl)2/DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -80 deg C, 1 h; 2.) CH₂Cl₂, -80 deg C to room temp.

With hydrogenchloride; calcium borohydride; oxalyl dichloride; camphor-10-sulfonic acid; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; ethanol; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.35.2219

Reference yield:

: 113957-02-1
(4R,5S,6S,7R,9R)-7-<2-(3,4-dimethoxybenzyloxy)ethyl>-5,9-dimethyl-4,6,10-trihydroxy-1-decene

: 113957-03-2
(2R,4R,5S,6S,7R)-4-<2-(3,4-dimethoxybenzyloxy)ethyl>-2,6-dimethyl-5,7-isopropylidenedioxy-9-decenal

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / CSA / benzene / 3 h / Ambient temperature

2: 1.) (COCl)2/DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -80 deg C, 1 h; 2.) CH₂Cl₂, -80 deg C to room temp.

With oxalyl dichloride; camphor-10-sulfonic acid; dimethyl sulfoxide; triethylamine; In benzene;
DOI:10.1248/cpb.35.2219