4-Thiazolecarboxylicacid,2-(2-bromophenyl)-,ethylester(9CI)

Base Information

• Chemical Name: 4-Thiazolecarboxylicacid,2-(2-bromophenyl)-,ethylester(9CI)
• CAS No.: 885278-78-4
• Molecular Formula: C₁₂H₁₀BrNO₂S
• Molecular Weight: 312.187
• Hs Code.: 2934100090
• Mol file: 885278-78-4.mol

Synonyms:4-Thiazolecarboxylicacid,2-(2-bromophenyl)-,ethylester(9CI)

Chemical Property of 4-Thiazolecarboxylicacid,2-(2-bromophenyl)-,ethylester(9CI)

Chemical Property:

• Vapor Pressure: 4.5E-07mmHg at 25°C
• Refractive Index: 1.602
• Boiling Point: 414.3°C at 760 mmHg
• Flash Point: 204.4°C
• PSA: 67.43000
• Density: 1.5g/cm³
• LogP: 3.74930
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-(2-bromophenyl)thiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxylicacid,2-(2-bromophenyl)-,ethylester(9CI)

There total 3 articles about 4-Thiazolecarboxylicacid,2-(2-bromophenyl)-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

L-cysteine ethyl ester hydrochloride (868-59-7) + ortho-bromobenzaldehyde (6630-33-7) → ethyl 2-(2-bromophenyl)thiazole-4-carboxylate (885278-78-4)

Guidance literature:

With tert.-butylhydroperoxide; iodine; potassium carbonate; In 1,4-dioxane; at 70 ℃; for 12h; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1039/c8ob02826e

Reference yield:

o-cyanobromobenzene (2042-37-7) → ethyl 2-(2-bromophenyl)thiazole-4-carboxylate (885278-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogen sulfide; magnesium chloride monohydrate

2: ethanol

With sodium hydrogen sulfide; magnesium chloride monohydrate; In ethanol;

DOI:10.1007/s00044-016-1669-9

Reference yield:

ethyl Bromopyruvate (70-23-5) + 2-bromobenzothioamide (30216-44-5) → ethyl 2-(2-bromophenyl)thiazole-4-carboxylate (885278-78-4)

Guidance literature:

In ethanol;

DOI:10.1007/s00044-016-1669-9

upstream raw materials:

o-cyanobromobenzene

ethyl Bromopyruvate

2-bromobenzothioamide

L-cysteine ethyl ester hydrochloride

Refernces

• 1、 Khan, Mahmood-ul-Hassan,Hameed, Shahid,Akhtar, Tashfeen,Al-Masoudi, Najim A.,Al-Masoudi, Wasfi A.,Jones, Peter G.,Pannecouque, Christophe. "Synthesis, crystal structure, anti-HIV, and antiproliferative activity of new oxadiazole and thiazole analogs". . p. 2399 - 2409. Retrieved 2016/10/25.