ETHYL 1H-INDAZOLE-7-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 1H-INDAZOLE-7-CARBOXYLATE
• CAS No.: 885278-74-0
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.202
• Hs Code.: 2933990090
• Mol file: 885278-74-0.mol

Synonyms:ETHYL 1H-INDAZOLE-7-CARBOXYLATE;1H-Indazole-7-carboxylic acid ethyl ester

Chemical Property of ETHYL 1H-INDAZOLE-7-CARBOXYLATE

Chemical Property:

• Melting Point: 111-113℃
• Refractive Index: 1.627
• Boiling Point: 353.9 °C at 760 mmHg
• Flash Point: 167.8 °C
• PSA: 54.98000
• Density: 1.272 g/cm³
• LogP: 1.73960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl1H-Indazole-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 1H-Indazole-7-carboxylate is useful for the synthesis of pyrrolopyrazines derivatives due to them acting as possible selective spleen tyrosine kinase inhibitors.

Technology Process of ETHYL 1H-INDAZOLE-7-CARBOXYLATE

There total 1 articles about ETHYL 1H-INDAZOLE-7-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxycarbonyl-6-methyl-aniline (64818-79-7) → ethyl 1H-indazole-7-carboxylate (885278-74-0)

Guidance literature:

With tert.-butylnitrite; acetic acid; at 10 - 20 ℃; for 12h;

DOI:10.7124/bc.000A55

Reference yield:

ethyl 1H-indazole-7-carboxylate (885278-74-0) → (1H-indazol-7-yl)methanol (1092961-09-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.5h;

DOI:10.1021/jm301720p

upstream raw materials:

2-ethoxycarbonyl-6-methyl-aniline

Downstream raw materials:

(1H-indazol-7-yl)methanol

Refernces