3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

Base Information

Chemical Name:3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester
CAS No.:1310328-57-4
Molecular Formula:C₂₄H₂₁NO₆
Molecular Weight:419.434
Hs Code.:

Synonyms:3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

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Chemical Property of 3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

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Technology Process of 3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

There total 8 articles about 3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.5%

: 1310328-55-2
4-bromobenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

: 13331-27-6
m-nitrobenzene boronic acid

: 1310328-57-4
3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

Guidance literature:: 4-bromobenzoic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 110 ℃;

m-nitrobenzene boronic acid; With sodium hydrogencarbonate; In 1,2-dimethoxyethane; water; at 110 ℃; for 5h;
DOI:10.1016/j.ejmech.2011.03.022

Reference yield:

: 1310328-60-9
carbonic acid tert-butyl ester 3-hydroxy-2,2-dimethylchroman-7-yl ester

: 1310328-57-4
3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

2.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 110 °C

3.2: 5 h / 110 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; 3.1: Suzuki coupling / 3.2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.03.022

Reference yield:

: 586-75-4
4-chlorobenzoyl chloride

: 1310328-57-4
3'-nitrobiphenyl-4-carboxylic acid 3-hydroxy-2,2-dimethylchroman-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 110 °C

2.2: 5 h / 110 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In 1,2-dimethoxyethane; dichloromethane; 2.1: Suzuki coupling / 2.2: Suzuki coupling;
DOI:10.1016/j.ejmech.2011.03.022