tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

Base Information

Chemical Name:tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate
CAS No.:1350881-21-8
Molecular Formula:C₂₃H₂₄ClNO₄
Molecular Weight:413.901
Hs Code.:

Synonyms:tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

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Chemical Property of tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

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Technology Process of tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

There total 5 articles about tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873-73-4
4-n-chlorophenylacetylene

: 1350881-20-7
tert-butyl {2-(benzyloxy)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate

: 1350881-21-8
tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

Guidance literature:: 4-n-chlorophenylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

tert-butyl {2-(benzyloxy)-3-[methoxy(methyl)amino]-3-oxopropyl}carbamate; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h;

Reference yield:

: 1350881-19-4
benzyl 2-(benzyloxy)-3-[(tert-butoxycarbonyl)amino]propanoate

: 1350881-21-8
tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 50 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 1.5 h / -78 - 0 °C

With n-butyllithium; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1350881-21-8
tert-butyl [2-(benzyloxy)-5-(4-chlorophenyI)-3-oxopent-4-yn-1-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 0 - 20 °C

3.1: sodium hydroxide; water / 1,4-dioxane / 50 °C

4.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

5.2: 1.5 h / -78 - 0 °C

With n-butyllithium; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;