methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate

Base Information

• Chemical Name: methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate
• CAS No.: 1034852-92-0
• Molecular Formula: C₁₆H₁₆O₆
• Molecular Weight: 304.299
• Mol file: 1034852-92-0.mol

Synonyms:methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate

Chemical Property of methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate

There total 1 articles about methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

cycl-isopropylidene malonate (2033-24-1) + methyl 4-methylphenylglyoxylate (34966-53-5) → methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate (1034852-92-0)

Guidance literature:

With pyridine; titanium tetrachloride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol800923q

Reference yield: 98.0%

methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate (1034852-92-0) + diethylzinc (557-20-0) → (S)-methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-2-p-tolylbutanoate (1034853-37-6)

Guidance literature:

diethylzinc; With (S)-(+)-(3,5-dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-[(1R)-1-phenethyl]amine; copper(II) bis(trifluoromethanesulfonate); In 1,2-dimethoxyethane; at -40 ℃; for 0.0833333h;

methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)-2-p-tolylacetate; In 1,2-dimethoxyethane; at -40 - 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol800923q

upstream raw materials:

cycl-isopropylidene malonate

methyl 4-methylphenylglyoxylate

Downstream raw materials:

(S)-methyl 2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)-2-p-tolylbutanoate

Refernces