Technology Process of 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indole
There total 6 articles about 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 50 ℃;
for 1h;
DOI:10.1039/c1ob05586k
- Guidance literature:
-
Multi-step reaction with 6 steps
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C
2: dmap / dichloromethane / 1 h / 20 °C
3: copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
5: tetrahydrofuran; methanol / 96 h / 20 °C / Inert atmosphere
6: potassium carbonate / methanol / 1 h / 50 °C
With
dmap; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; tetrabutyl ammonium fluoride; iodine; potassium carbonate; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
3: Sonogashira coupling;
DOI:10.1039/c1ob05586k
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dmap / dichloromethane / 1 h / 20 °C
2: copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere
4: tetrahydrofuran; methanol / 96 h / 20 °C / Inert atmosphere
5: potassium carbonate / methanol / 1 h / 50 °C
With
dmap; copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane;
2: Sonogashira coupling;
DOI:10.1039/c1ob05586k