3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

Base Information

Chemical Name:3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide
CAS No.:1354786-21-2
Molecular Formula:C₂₆H₁₈FN₅O₃S₂
Molecular Weight:531.591
Hs Code.:

Synonyms:3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

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Chemical Property of 3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

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Technology Process of 3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

There total 6 articles about 3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1354786-75-6
3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-ol

: 1354786-80-3
3-cyano-4-fluoro-N-(5-fluoro-1,3-thiazol-2-yl)benzenesulfonamide

: 1354786-21-2
3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 16h;

Reference yield:

: 1354786-74-5
5-[4-(benzyloxy)biphenyl-3-yl]-1-methyl-1H-pyrazole

: 1354786-21-2
3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium on activated charcoal / methanol / 16 h

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 114250-18-9
2-bromo-1-(phenylmethoxy)-4-phenylbenzene

: 1354786-21-2
3-Cyano-N-(5-fluoro-1,3-thiazol-2-yl)-4-{[3-(1-methyl-1H-pyrazol-5-yl)biphenyl-4-yl]oxy}benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: dipotassium hydrogenphosphate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 100 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / methanol / 16 h

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

With dipotassium hydrogenphosphate; hydrogen; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; tricyclohexylphosphine; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: Suzuki Coupling;