3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone

Base Information

• Chemical Name: 3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone
• CAS No.: 627535-24-4
• Molecular Formula: C₃₉H₅₄N₆O₉
• Molecular Weight: 750.893

Synonyms:3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone

Chemical Property of 3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone

There total 3 articles about 3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-azidocarbonyl-2-(4-hydroxy-2,6-dimethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester + 3,6-bis(amino-CH2)-5-methyl-2(1H)-pyrazinone*2HBr → 3,6-bis[Nα-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone (627535-24-4)

Guidance literature:

With 4-methyl-morpholine; In 1,4-dioxane; N,N-dimethyl-formamide; at 0 ℃; for 24h; pH=8;

DOI:10.1021/jm0304616

Reference yield:

3,6-bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one (501022-57-7) → 3,6-bis[Nα-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone (627535-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: HBr; AcOH / 2 h / 20 °C

2: 4-methylmorpholine / dimethylformamide; dioxane / 24 h / 0 °C / pH 8

With 4-methyl-morpholine; hydrogen bromide; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm0304616

Reference yield:

[1-hydrazinocarbonyl-2-(4-hydroxy-2,6-dimethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester → 3,6-bis[Nα-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone (627535-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl; isopentyl nitrite / dimethylformamide; dioxane / 0.17 h / -15 °C

2: 4-methylmorpholine / dimethylformamide; dioxane / 24 h / 0 °C / pH 8

With 4-methyl-morpholine; hydrogenchloride; isopentyl nitrite; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm0304616

upstream raw materials:

3,6-bis(benzyloxycarbonylaminomethyl)-5-methyl-1,2-dihydropyrazin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 627535-24-4 3,6-bis[N^α-Boc-(2',6'-dimethyl-L-tyrosine)aminomethyl]-5-methyl-2(1H)-pyrazinone

Send

Send

Metric Ton KG G Pound L ML

Send

Send