2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester

Base Information Edit

Chemical Name:2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester
CAS No.:133125-17-4
Molecular Formula:C₁₆H₂₂INO₄
Molecular Weight:419.259
Hs Code.:
Mol file:133125-17-4.mol

Synonyms:2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester

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Chemical Property of 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester Edit

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Technology Process of 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester

There total 8 articles about 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 78266-81-6
tert-butyl N-[(benzyloxy)carbonyl]-L-homoserinate

: 133125-17-4
2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2017.05.045

Reference yield: 80.0%

: 2(S)-2-(benzyloxycarbonylamino)-4-mesyloxybutyric acid tert-butyl ester

: 133125-17-4
2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester

Guidance literature:: With sodium iodide; In acetone; for 5h; Heating;
DOI:10.1002/ardp.19953280414

Reference yield:

: 47307-26-6,149967-07-7
(S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester

: 133125-17-4
2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran

1.2: 0 °C

2.1: iodine; triphenylphosphine / dichloromethane / 0.17 h / Inert atmosphere

2.2: 3 h / Inert atmosphere; Reflux

With iodine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c1cc10565e