{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

Base Information

Chemical Name:{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid
CAS No.:1062558-60-4
Molecular Formula:C₂₃H₂₃N₃O₅S
Molecular Weight:453.519
Hs Code.:

Synonyms:{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

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Chemical Property of {7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

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Technology Process of {7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

There total 5 articles about {7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1062558-78-4
{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid ethyl ester

: 1062558-60-4
{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

Guidance literature:: {7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid ethyl ester; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: 1062558-60-4
{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; hexanes / 2 h / Heating / reflux

2: sodium hydrogencarbonate / acetonitrile / 14 h / Heating / reflux

3: copper / toluene / 2 h / Heating / reflux

4: triethylsilane; trifluoroacetic acid / 1,2-dichloro-ethane / 0 - 20 °C

5: lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With triethylsilane; lithium hydroxide; water; copper; sodium hydrogencarbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; hexanes; 1,2-dichloro-ethane; toluene; acetonitrile;

Reference yield:

: 22320-37-2
2-methyl-indolizine-7-carbonitrile

: 1062558-60-4
{7-cyano-2-methyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: copper / toluene / 2 h / Heating / reflux

2: triethylsilane; trifluoroacetic acid / 1,2-dichloro-ethane / 0 - 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 1 h / 20 °C

With triethylsilane; lithium hydroxide; water; copper; trifluoroacetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;