benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

Base Information

Chemical Name:benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate
CAS No.:74560-17-1
Molecular Formula:C₄₈H₄₃N₂O₉P
Molecular Weight:822.851
Hs Code.:

Synonyms:benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

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Chemical Property of benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

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Technology Process of benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

There total 11 articles about benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72217-27-7,72257-77-3
benzyl 2-chloro-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

: 74560-17-1
benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

Guidance literature:: With sodium hydrogencarbonate; triphenylphosphine; In dichloromethane; nitrogen; water; ethyl acetate; benzene;

Reference yield:

: 72217-21-1,72217-22-2
2-[(S)-3-Amino-2-(2-hydroxy-ethoxy)-4-oxo-azetidin-1-yl]-3-methyl-but-2-enoic acid benzyl ester

: 74560-17-1
benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 1.33 h / 0 °C

2: 1.) O₃, 2.) aq. NaHSO₃ / 1.) AcOEt, from -65 to 0 deg C, 2.) AcOEt

3: 9.46 g / Zn, AcOH / CH₂Cl₂ / 2 h / 5 °C

4: 2,6-lutidine, SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

5: CH₂Cl₂ / 4 h / Heating

With pyridine; 2,6-dimethylpyridine; thionyl chloride; ozone; sodium hydrogensulfite; acetic acid; zinc; In dichloromethane;
DOI:10.1021/jm00184a009

Reference yield:

: 74280-93-6
1,2-secopenicillin tosylate

: 74560-17-1
benzyl 2-triphenylphosphoranylidene-2-[2-oxo-3β-phenoxyacetamido-4β-(2-phenoxyacetoxyethoxy)azetidin-1-yl]acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / Cl₂ / CH₂Cl₂; CCl₄ / 1 h / -65 °C

2: AgBF₄ / CH₂Cl₂ / 2.08 h / -45 - 0 °C

3: pyridine / 1.33 h / 0 °C

4: 1.) O₃, 2.) aq. NaHSO₃ / 1.) AcOEt, from -65 to 0 deg C, 2.) AcOEt

5: 9.46 g / Zn, AcOH / CH₂Cl₂ / 2 h / 5 °C

6: 2,6-lutidine, SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

7: CH₂Cl₂ / 4 h / Heating

With pyridine; 2,6-dimethylpyridine; silver tetrafluoroborate; thionyl chloride; chlorine; ozone; sodium hydrogensulfite; acetic acid; zinc; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00184a009