ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate

Base Information

• Chemical Name: ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate
• CAS No.: 1026470-46-1
• Molecular Formula: C₂₂H₂₇N₅O₄
• Molecular Weight: 425.487
• Mol file: 1026470-46-1.mol

Synonyms:ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate

Chemical Property of ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate

Chemical Property:

Purity/Quality:

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• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate

There total 1 articles about ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

ethyl 4-[5-(3-cyano-4-fluorobenzylamino)-2-methoxyphenoxy]butanoate (1233220-91-1) + guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) → ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate (1026470-46-1)

Guidance literature:

In N,N-dimethyl acetamide; at 140 ℃; for 5h;

DOI:10.1016/j.bmc.2010.04.020

Reference yield: 72.0%

ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate (1026470-46-1) → 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoic acid (1233220-97-7)

Guidance literature:

ethyl 4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoate; With methanol; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; In methanol; water;

DOI:10.1016/j.bmc.2010.04.020

upstream raw materials:

ethyl 4-[5-(3-cyano-4-fluorobenzylamino)-2-methoxyphenoxy]butanoate

guanidine hydrogen carbonate

Downstream raw materials:

4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-methoxyphenoxy)butanoic acid