(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

Base Information

Chemical Name:(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester
CAS No.:180193-80-0
Molecular Formula:C₃₆H₄₁NO₃
Molecular Weight:535.726
Hs Code.:

Synonyms:(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

Chemical Property:

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Technology Process of (2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

There total 6 articles about (2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 180193-77-5
(2R,5S)-5-Dibenzylamino-4-oxo-2,6-diphenyl-hexanoic acid butyl ester

: 180193-80-0
(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1016/0040-4039(96)00828-3

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 180193-80-0
(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / K₂CO₃, NaOH / H₂O

2: 81 percent / BuLi / tetrahydrofuran / -78 °C

3: 87 percent / DBU / tetrahydrofuran / -15 °C / Wadsworth-Emmons condensation

4: 60 percent / Et₂Al, CuBr, DMS / tetrahydrofuran / -20 °C

5: 75 percent / NaBH₄ / methanol

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; 2,3-dimercapto-succinic acid; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; In tetrahydrofuran; methanol; water;
DOI:10.1016/0040-4039(96)00828-3

Reference yield:

: 111138-83-1
N,N-dibenzyl-L-phenylalanine benzyl ester

: 180193-80-0
(2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / BuLi / tetrahydrofuran / -78 °C

2: 87 percent / DBU / tetrahydrofuran / -15 °C / Wadsworth-Emmons condensation

3: 60 percent / Et₂Al, CuBr, DMS / tetrahydrofuran / -20 °C

4: 75 percent / NaBH₄ / methanol

With sodium tetrahydroborate; n-butyllithium; 2,3-dimercapto-succinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper(I) bromide; In tetrahydrofuran; methanol;
DOI:10.1016/0040-4039(96)00828-3