3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

Base Information

Chemical Name:3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one
CAS No.:1374457-26-7
Molecular Formula:C₁₅H₁₄BrNO₄
Molecular Weight:352.184
Hs Code.:

Synonyms:3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

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Chemical Property of 3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

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Technology Process of 3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

There total 4 articles about 3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1395316-32-1
C₁₉H₂₂BrNO₆

: 1374457-26-7
3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In water; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmc.2012.06.032

Reference yield:

: 269409-73-6
3-carboxyphenylboronic acid pinacol ester

: 1374457-26-7
3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation; Autoclave

3: chlorotriisopropylsilane; trifluoroacetic acid / water / 1.5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; chlorotriisopropylsilane; tetrabutylammomium bromide; benzotriazol-1-ol; triethylamine; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2012.06.032

Reference yield:

: 1073353-61-3
pyrrolidin-1-yl-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone

: 1374457-26-7
3-bromo-5-hydroxy-4-[3-(pyrrolidine-1-carbonyl)-phenyl]-5H-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation; Autoclave

2: chlorotriisopropylsilane; trifluoroacetic acid / water / 1.5 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; chlorotriisopropylsilane; tetrabutylammomium bromide; cesium fluoride; trifluoroacetic acid; In tetrahydrofuran; water; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2012.06.032