2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Base Information

Chemical Name:2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide
CAS No.:212578-55-7
Molecular Formula:C₂₉H₃₄N₂O₆
Molecular Weight:506.599
Hs Code.:

Synonyms:2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

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Chemical Property of 2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

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Technology Process of 2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

There total 7 articles about 2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 212578-51-3
[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-acetic acid

: 212578-55-7
2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm970795t

Reference yield:

: 80241-83-4
N**2-(3,4-dimethoxy-benzylidene)aminophenol

: 212578-55-7
2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / ethanol

2: NaHCO₃ / ethanol / 8 h / Ambient temperature

3: K₂CO₃ / ethanol / 1 h / Ambient temperature

4: 68 percent / KOH / ethanol / Ambient temperature

5: 78 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm970795t

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 212578-55-7
2-[4-(3,4-Dimethoxy-benzyl)-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl]-N-[2-(3,4-dimethoxy-phenyl)-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 6 steps

2: NaBH₄ / ethanol

3: NaHCO₃ / ethanol / 8 h / Ambient temperature

4: K₂CO₃ / ethanol / 1 h / Ambient temperature

5: 68 percent / KOH / ethanol / Ambient temperature

6: 78 percent / EDCI / CH₂Cl₂ / 5 h / Ambient temperature

With potassium hydroxide; sodium tetrahydroborate; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm970795t