(2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Base Information

• Chemical Name: (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol
• CAS No.: 870181-69-4
• Molecular Formula: C₃₉H₃₅NO₇
• Molecular Weight: 629.709
• Mol file: 870181-69-4.mol

Synonyms:(2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Chemical Property of (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol

There total 6 articles about (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-hydroxymethyl-tetrahydro-furan-3-ol (870181-67-2) + 4,4'-dimethoxytrityl chloride (40615-36-9) → (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol (870181-69-4)

Guidance literature:

With pyridine; at 20 ℃; for 1h;

DOI:10.1021/ja054607x

Reference yield:

C19H17FO5 (870181-62-7) → (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol (870181-69-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 54 percent / Cp₂HfCl₂; AgClO₄; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / -78 - 0 °C

2: 76 percent / NaOMe / methanol / 0.5 h / 20 °C

3: 84 percent / pyridine / 1 h / 20 °C

With pyridine; bis(cyclopentadienyl)hafnium dichloride; 4 A molecular sieve; sodium methylate; silver perchlorate; In methanol; dichloromethane;

DOI:10.1021/ja054607x

Reference yield:

C32H25NO7 (870181-65-0) → (2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol (870181-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / NaOMe / methanol / 0.5 h / 20 °C

2: 84 percent / pyridine / 1 h / 20 °C

With pyridine; sodium methylate; In methanol;

DOI:10.1021/ja054607x

upstream raw materials:

(2R,3S,5R)-5-(3-Benzooxazol-2-yl-2-hydroxy-phenyl)-2-hydroxymethyl-tetrahydro-furan-3-ol

4,4'-dimethoxytrityl chloride

C₁₉H₁₇FO₅

C₃₂H₂₅NO₇