Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

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Chemical Name:Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester
CAS No.:200562-44-3
Molecular Formula:C₅₆H₅₇N₇O₁₆
Molecular Weight:1084.11
Hs Code.:

Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Synonyms:Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

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Chemical Property of Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

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Technology Process of Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

There total 8 articles about Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 49761-23-1
bis(4-nitrophenyl) heptane-1,7-dioate

: 200562-25-0
N-{9-[(2S,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide

: 200562-44-3
Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Guidance literature:: With dmap; In pyridine; for 16h; Ambient temperature;
DOI:10.1002/hlca.19970800803

Reference yield:

: (3S,4R,5S)-5-Triisopropylsilanyloxymethyl-tetrahydro-furan-2,3,4-triol

: 200562-44-3
Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂; pyridine / 14 h / Ambient temperature

2: 58 percent / BSA, trimethylsilyl triflate / CH₂Cl₂ / 2.5 h / 80 °C

3: 92 percent / conc. aq. HCl / tetrahydrofuran / 1 h / Ambient temperature

4: 1.) (i-Pr)2NEt; 2.) 10N aq. NaOH / 1.) CH₂Cl₂, r.t., 30 min; 2.) CH₂Cl₂, THF, MeOH, 4 deg C, 25 min

5: 1.) (i-Pr)2NEt, Bu₂SnCl₂ / 1.) MeCN, r.t., 90 min; 2.) MeCN, 4 deg C, 3 h

6: 76 percent / DMAP / pyridine / 16 h / Ambient temperature

With hydrogenchloride; benzenesulfonamide; dmap; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1002/hlca.19970800803

Reference yield:

: 1,2,3-tri-O-benzoyl-5-O-(triisopropylsilyl)-α/β-L-ribose

: 200562-44-3
Heptanedioic acid (2S,3S,4S,5S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-(2-nitro-benzyloxymethoxy)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / BSA, trimethylsilyl triflate / CH₂Cl₂ / 2.5 h / 80 °C

2: 92 percent / conc. aq. HCl / tetrahydrofuran / 1 h / Ambient temperature

3: 1.) (i-Pr)2NEt; 2.) 10N aq. NaOH / 1.) CH₂Cl₂, r.t., 30 min; 2.) CH₂Cl₂, THF, MeOH, 4 deg C, 25 min

4: 1.) (i-Pr)2NEt, Bu₂SnCl₂ / 1.) MeCN, r.t., 90 min; 2.) MeCN, 4 deg C, 3 h

5: 76 percent / DMAP / pyridine / 16 h / Ambient temperature

With hydrogenchloride; benzenesulfonamide; dmap; sodium hydroxide; trimethylsilyl trifluoromethanesulfonate; dibutyltin chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1002/hlca.19970800803