2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

Base Information

Chemical Name:2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide
CAS No.:1338344-82-3
Molecular Formula:C₂₆H₂₉ClN₆O₃
Molecular Weight:509.008
Hs Code.:

Synonyms:2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

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Chemical Property of 2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

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Technology Process of 2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

There total 5 articles about 2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 3-amino-4-{[2-(methyloxy)ethyl]amino}-N-[2-(4-morpholinyl)ethyl]-5-nitrobenzamide

: 279251-15-9
2-(4-chlorophenyl)-1H-imidazole-4-carbaldehyde

: 1338344-82-3
2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: With sodium hydrogensulfite; In ethanol; water; at 150 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1338344-82-3
2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 0.25 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.08 h / 150 °C / Microwave irradiation

3.1: zinc; acetic acid / 0.5 h / 20 °C

4.1: sodium hydrogensulfite / ethanol; water / 0.08 h / 150 °C / Microwave irradiation

With oxalyl dichloride; sodium hydrogensulfite; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; N,N-dimethyl-formamide; In ethanol; dichloromethane; water;

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1338344-82-3
2-[2-(4-chlorophenyl)-1H-imidazol-4-yl]-1-[2-(methyloxy)ethyl]-N-[2-(4-morpholinyl)ethyl]-1H-benzimidazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere; Cooling with ice

1.2: 0.25 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.08 h / 150 °C / Microwave irradiation

3.1: zinc; acetic acid / 0.5 h / 20 °C

4.1: sodium hydrogensulfite / ethanol; water / 0.08 h / 150 °C / Microwave irradiation

With oxalyl dichloride; sodium hydrogensulfite; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; N,N-dimethyl-formamide; In ethanol; dichloromethane; water;