N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide

Base Information

Chemical Name:N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide
CAS No.:1173290-17-9
Molecular Formula:C₃₁H₂₄F₄N₂O₄S
Molecular Weight:596.602
Hs Code.:

Synonyms:N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide

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Chemical Property of N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide

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Technology Process of N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide

There total 2 articles about N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1431544-30-7
N-[2-(2-acetyl-4-fluorophenoxy)-3-benzylquinolin-6-yl]-(3-trifluoromethylphenyl)sulfonamide

: 1173290-17-9
N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 5 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.02.054

Reference yield:

: 1173292-06-2
1-[2-(6-amino-3-benzyl-quinolin-2-yloxy)-5-fluoro-phenyl]-ethanone

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 1173290-17-9
N-{3-benzyl-2-[4-fluoro-2-(1-hydroxyethyl)phenoxy]quinolin-6-yl}-(3-trifluoromethylphenyl)sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 12 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 2 h / 5 - 20 °C

With pyridine; sodium tetrahydroborate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2013.02.054