(9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester

Base Information

• Chemical Name: (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester
• CAS No.: 123418-34-8
• Molecular Formula: C₃₃H₃₇N₃O₉
• Molecular Weight: 619.671

Synonyms:(9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester

Chemical Property of (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester

Chemical Property:

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Technology Process of (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester

There total 6 articles about (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(9S,12S,15S)-12-(4-Benzyloxy-benzyl)-19,20-dibromo-9-tert-butoxycarbonylamino-5-chloro-4-hydroxy-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-15-carboxylic acid methyl ester (123440-71-1) → (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-15-carboxylic acid methyl ester (123418-34-8)

Guidance literature:

With hydrogen; sodium acetate; palladium; In methanol; for 48h; Ambient temperature;

DOI:10.1016/S0040-4039(00)95207-9

Reference yield:

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) → (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-15-carboxylic acid methyl ester (123418-34-8)

Guidance literature:

Multi-step reaction with 5 steps

1: DCC, 1-hydroxybenztriazole, N-methylmorpholine / dimethylformamide / 0 deg C to room temp., overnight

2: HCl / dioxane / Ambient temperature; overnight

3: 78 percent / DCC, 1-hydrobenztriazole, N-methylmorpholine / dimethylformamide / 0 deg C to room temp., overnight

4: 1) TTN, 2) Zn / 1) MeOH - dioxane, 0 deg C to room temp., overnight, 2) AcOH - THF, room temp., 3 h

5: 96 percent / H₂, NaOAc / Pd-black / methanol / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; 1,2,3-Benzotriazole; hydrogen; sodium acetate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; thallium(III) nitrate; zinc; palladium; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)95207-9

Reference yield:

3',5'-dibromo-L-tyrosine methyl ester (67470-21-7,173383-29-4) → (9S,12S,15S)-9-tert-Butoxycarbonylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.13,7]docosa-1(20),3,5,7(22),17(21),18-hexaene-15-carboxylic acid methyl ester (123418-34-8)

Guidance literature:

Multi-step reaction with 5 steps

1: DCC, 1-hydroxybenztriazole, N-methylmorpholine / dimethylformamide / 0 deg C to room temp., overnight

2: HCl / dioxane / Ambient temperature; overnight

3: 78 percent / DCC, 1-hydrobenztriazole, N-methylmorpholine / dimethylformamide / 0 deg C to room temp., overnight

4: 1) TTN, 2) Zn / 1) MeOH - dioxane, 0 deg C to room temp., overnight, 2) AcOH - THF, room temp., 3 h

5: 96 percent / H₂, NaOAc / Pd-black / methanol / 48 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; 1,2,3-Benzotriazole; hydrogen; sodium acetate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; thallium(III) nitrate; zinc; palladium; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)95207-9

upstream raw materials:

(9S,12S,15S)-12-(4-Benzyloxy-benzyl)-19,20-dibromo-9-tert-butoxycarbonylamino-5-chloro-4-hydroxy-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

3',5'-dibromo-L-tyrosine methyl ester

(S)-2-[(S)-2-Amino-3-(4-benzyloxy-phenyl)-propionylamino]-3-(3,5-dibromo-4-hydroxy-phenyl)-propionic acid methyl ester; hydrochloride

Downstream raw materials:

(9S,12S,15S)-9-Acetylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid methyl ester

(9S,12S,15S)-9-Acetylamino-4-hydroxy-12-(4-hydroxy-benzyl)-10,13-dioxo-2-oxa-11,14-diaza-tricyclo[15.2.2.1^3,7]docosa-1⁽²⁰⁾,3,5,7⁽²²⁾,17⁽²¹⁾,18-hexaene-15-carboxylic acid

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