2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine

Base Information

• Chemical Name: 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine
• CAS No.: 1454585-22-8
• Molecular Formula: C₁₉H₁₁ClF₃N₇
• Molecular Weight: 429.791
• Mol file: 1454585-22-8.mol

Synonyms:2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine

Chemical Property of 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine

There total 6 articles about 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dichloro-9-(3-fluorophenyl)-9H-purine (1446513-80-9) + (4,5-difluoro-1H-benzo[d]imidazol-2-yl)methanamine hydrochloride (1446513-83-2) → 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine (1454585-22-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; for 0.5h; Sealed tube; Microwave irradiation;

Reference yield:

(4,5-difluoro-1H-benzo[d]imidazol-2-yl)methanamine + 2,6-dichloro-9-(3-fluorophenyl)-9H-purine (1446513-80-9) → 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine (1454585-22-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; for 0.5h; Microwave irradiation; Sealed tube;

DOI:10.1016/j.bmc.2017.12.020

Reference yield:

3,4-difluoro-1,2-phenylenediamine (153505-39-6) → 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine (1454585-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C

1.2: 20 °C

1.3: 2 h / 70 °C

2.1: hydrogenchloride / water; 1,4-dioxane / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.5 h / 90 °C / Sealed tube; Microwave irradiation

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol;

upstream raw materials:

3,4-difluoro-1,2-phenylenediamine

2,6 dichloropurine

tert-butyl (4,5-difluoro-1H-benzo[d]imidazol-2-yl)methylcarbamate

2,6-dichloro-9-(3-fluorophenyl)-9H-purine

Downstream raw materials:

N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-2-morpholino-9H-purin-6-amine