(E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

Base Information

Chemical Name:(E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate
CAS No.:908597-42-2
Molecular Formula:C₂₅H₂₅ClN₂O₄
Molecular Weight:452.938
Hs Code.:

Synonyms:(E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

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Chemical Property of (E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

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Technology Process of (E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

There total 5 articles about (E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(1,3-dibenzyl-5-chloro-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-oxo-propionic acid but-2-enyl ester

: 74-88-4
methyl iodide

: 908597-42-2
(E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

Guidance literature:: 3-(1,3-dibenzyl-5-chloro-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-oxo-propionic acid but-2-enyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 23 ℃;

methyl iodide; In tetrahydrofuran; at 23 ℃;
DOI:10.1002/anie.200601208

Reference yield:

: 908597-62-6
1,3-dibenzyl-4-chloro-2-oxo-2,3-dihydro-1H-imidazole-5-carbaldehyde

: 908597-42-2
(E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 °C

2.1: Dess-Martin periodinane / CH₂Cl₂; H₂O / 23 °C

3.1: sodium hydride / tetrahydrofuran / 0 - 23 °C

3.2: 48 mg / tetrahydrofuran / 23 °C

With sodium hydride; Dess-Martin periodane; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; water;
DOI:10.1002/anie.200601208

Reference yield:

: 3-(1,3-dibenzyl-5-chloro-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-3-hydroxy-propionic acid but-2-enyl ester

: 908597-42-2
(E)-but-2-enyl 3-(5-chloro-1,3-dibenzyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-2-methyl-3-oxopropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Dess-Martin periodinane / CH₂Cl₂; H₂O / 23 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 23 °C

2.2: 48 mg / tetrahydrofuran / 23 °C

With sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/anie.200601208