2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal

Base Information

• Chemical Name: 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal
• CAS No.: 245485-76-1
• Molecular Formula: C₁₃H₂₀O
• Molecular Weight: 192.301
• Mol file: 245485-76-1.mol

Synonyms:2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal

Chemical Property of 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal

There total 5 articles about 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethan-1-ol (245485-72-7) → 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal (245485-76-1)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;

DOI:10.1016/S0040-4020(01)00821-3

Reference yield:

2-[(1R,2S,6R)-1,2-dimethyl-6-(1-methylvinyl)-3-oxocyclohexyl]ethyl acetate (197232-95-4) → 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal (245485-76-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / lithium tri-tert-butoxyaluminum hydride / tetrahydrofuran / 0.33 h / 0 °C

2: 93 percent / POCl₃; pyridine / 2 h / 20 °C

3: 99 percent / K₂CO₃ / ethanol / 3 h / 20 °C

4: 93 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

With pyridine; oxalyl dichloride; lithium tri(t-butoxy)aluminum hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 4: Swern oxidation;

DOI:10.1016/S0040-4020(01)00821-3

Reference yield:

2-[(1R,2S,3R,6R)-3-hydroxy-1,2-dimethyl-6-(1-methylvinyl)cyclohexyl]ethyl acetate (245485-69-2) → 2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethanal (245485-76-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / POCl₃; pyridine / 2 h / 20 °C

2: 99 percent / K₂CO₃ / ethanol / 3 h / 20 °C

3: 93 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

With pyridine; oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; triethylamine; trichlorophosphate; In ethanol; dichloromethane; 3: Swern oxidation;

DOI:10.1016/S0040-4020(01)00821-3

upstream raw materials:

2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethan-1-ol

2-[(1R,2S,6R)-1,2-dimethyl-6-(1-methylvinyl)-3-oxocyclohexyl]ethyl acetate

2-[(1R,6R)-1,2-dimethyl-6-(1-methylvinyl)cyclohex-2-enyl]ethyl acetate

2-[(1R,2S,3R,6R)-3-hydroxy-1,2-dimethyl-6-(1-methylvinyl)cyclohexyl]ethyl acetate