3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)

Base Information

• Chemical Name: 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)
• CAS No.: 115435-22-8
• Molecular Formula: C₄₆H₆₉NO₁₆S
• Molecular Weight: 924.117
• Mol file: 115435-22-8.mol

Synonyms:3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)

Chemical Property of 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)

There total 3 articles about 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,23-di-O-acetyl-5-O-(β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal) (115435-21-7) + benzenesulfonyl chloride (1939-99-7) → 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal) (115435-22-8)

Guidance literature:

In pyridine; at -40 ℃; for 4h;

DOI:10.1016/0008-6215(87)80255-0

Reference yield:

5-O-(β-D-mycaminosyl)tylonolide 9,10-bis(ethylene acetal) (108220-98-0) → 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal) (115435-22-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / pyridine / 50 °C

2: 94 percent / methanol / 50 °C

3: 97 percent / pyridine / 4 h / -40 °C

In pyridine; methanol;

DOI:10.1016/0008-6215(87)80255-0

Reference yield:

3,23-di-O-acetyl-5-O-(2,4-di-O-acetyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal) (115435-20-6) → 3,23-di-O-acetyl-5-O-(4-O-benzylsulphonyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal) (115435-22-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / methanol / 50 °C

2: 97 percent / pyridine / 4 h / -40 °C

In pyridine; methanol;

DOI:10.1016/0008-6215(87)80255-0

upstream raw materials:

3,23-di-O-acetyl-5-O-(β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)

benzenesulfonyl chloride

5-O-(β-D-mycaminosyl)tylonolide 9,10-bis(ethylene acetal)

3,23-di-O-acetyl-5-O-(2,4-di-O-acetyl-β-D-mycaminosyl)tylonolide 9,20-bis(ethylene acetal)