N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide
CAS No.:1400667-93-7
Molecular Formula:C₂₃H₁₈ClF₂N₅O₃S
Molecular Weight:517.943
Hs Code.:

Synonyms:N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

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Chemical Property of N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

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Technology Process of N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

There total 10 articles about N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1400668-16-7
6-chloro-4-(cyclopentyloxy)pyrido[3,2-d]pyrimidine

: 1093819-56-7
N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1400667-93-7
N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

Guidance literature:: With sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 110 ℃; for 1h; Microwave irradiation;

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1400667-93-7
N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; tin(ll) chloride / 1 h / Reflux

2: pyridine / dichloromethane / 0 - 20 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / Reflux

4: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

With pyridine; ethanol; potassium acetate; sodium hydrogencarbonate; tin(ll) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 93683-65-9
6-chloro-3-nitropicolinonitrile

: 1400667-93-7
N-(2-chloro-5-(4-(cyclopentyloxy)pyrido[3,2-d]pyrimidin-6-yl)pyridin-3-yl)-2,4-difluoro benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide; water / 0.33 h / 20 °C

1.2: 3 h / 20 °C

2.1: 3 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 1 h / 20 - 110 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

4.2: 2 h / 0 - 20 °C

5.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

With ammonium hydroxide; water; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;