Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

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Chemical Name:Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester
CAS No.:672956-53-5
Molecular Formula:C₄₈H₄₃N₅O₉
Molecular Weight:833.898
Hs Code.:

Synonyms:Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

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Chemical Property of Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

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Technology Process of Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

There total 10 articles about Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 672956-51-3
Benzoic acid (2R,3R,4R,5R)-2-(2-allyloxy-6-dibenzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-hydroxy-tetrahydro-pyran-3-yl ester

: 672956-53-5
Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

Guidance literature:: With dmap; 4-nitro-phenol; triethylamine; In pyridine; propan-1-ol; at 60 ℃; for 24h;
DOI:10.1002/hlca.200390349

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 672956-53-5
Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99.7 percent / 4A MS; EtN(i-Pr)2 / CH₂Cl₂ / 1.25 h / 25 °C

2: 54 percent / 4-nitrophenol; DMAP; Et₃N / pyridine; propan-1-ol / 24 h / 60 °C

With dmap; 4-nitro-phenol; triethylamine; N-ethyl-N,N-diisopropylamine; In pyridine; propan-1-ol; dichloromethane;
DOI:10.1002/hlca.200390349

Reference yield:

: 16755-02-5
6-amino-2-chloro-9-(β-D-ribopyranosyl)purine

: 672956-53-5
Benzoic acid (2R,3R,4S,5R)-2-(2-allyloxy-6-benzoylamino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: Cs₂CO₃; 3A MS / 6 h / 90 °C

2.1: pyridine / 0 - 20 °C

2.2: 1.12 g / NaOH; water / tetrahydrofuran; methanol / 0.5 h / 0 °C

3.1: TsOH / dimethylformamide / 2 h / 60 °C

3.2: 72 percent / pyridine / 0 - 20 °C

4.1: 80.7 percent / CF₃COOH / methanol; tetrahydrofuran / 3 h / 25 °C

5.1: 99.7 percent / 4A MS; EtN(i-Pr)2 / CH₂Cl₂ / 1.25 h / 25 °C

6.1: 54 percent / 4-nitrophenol; DMAP; Et₃N / pyridine; propan-1-ol / 24 h / 60 °C

With pyridine; dmap; 4-nitro-phenol; caesium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; methanol; propan-1-ol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390349