(1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

Base Information

• Chemical Name: (1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol
• CAS No.: 872315-13-4
• Molecular Formula: C₃₈H₇₄O₆Si₂
• Molecular Weight: 683.173

Synonyms:(1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

Chemical Property of (1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of (1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol

There total 1 articles about (1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(1S,2S,3S)-3-tert-Butoxy-2-((R)-2-methoxymethoxy-2-tributylstannanyl-ethyl)-2-methyl-6-methylene-cyclohexylmethoxy]-tert-butyl-dimethyl-silane + (S)-4-tert-butyldimethylsilyloxy-2,6,6-trimethyl-2-cyclohexenone (169124-54-3) → (1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol (872315-13-4) + (1R,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol (872315-14-5)

Guidance literature:

[(1S,2S,3S)-3-tert-Butoxy-2-((R)-2-methoxymethoxy-2-tributylstannanyl-ethyl)-2-methyl-6-methylene-cyclohexylmethoxy]-tert-butyl-dimethyl-silane; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

(S)-4-tert-butyldimethylsilyloxy-2,6,6-trimethyl-2-cyclohexenone; In tetrahydrofuran; at -78 ℃; for 0.333333h;

DOI:10.1016/j.tetasy.2005.09.012

Reference yield: 81.0%

(1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol (872315-13-4) → (4S,5S,8S)-4-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexylmethyl]-8-(tert-butyl-dimethyl-silanyloxy)-6,10,10-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ene (872315-15-6)

Guidance literature:

With 2,3,5-trimethyl-pyridine; trimethylsilyl trifluoromethanesulfonate; In toluene; at -30 - 0 ℃; for 2h;

DOI:10.1016/j.tetasy.2005.09.012

Reference yield: 80.0%

(1S,4S)-1-{(S)-2-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexyl]-1-methoxymethoxy-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-2,6,6-trimethyl-cyclohex-2-enol (872315-13-4) → (1S,4S)-1-[(S)-2-((1S,2S,6S)-6-tert-Butoxy-2-hydroxymethyl-1-methyl-3-methylene-cyclohexyl)-1-methoxymethoxy-ethyl]-2,6,6-trimethyl-cyclohex-2-ene-1,4-diol (872315-21-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 2h;

DOI:10.1016/j.tetasy.2005.09.012

upstream raw materials:

(S)-4-tert-butyldimethylsilyloxy-2,6,6-trimethyl-2-cyclohexenone

Downstream raw materials:

(1S,4S)-1-[(S)-2-((1S,2S,6S)-6-tert-Butoxy-2-hydroxymethyl-1-methyl-3-methylene-cyclohexyl)-1-methoxymethoxy-ethyl]-2,6,6-trimethyl-cyclohex-2-ene-1,4-diol

(4S,5S,8S)-4-[(1S,2S,6S)-6-tert-Butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-1-methyl-3-methylene-cyclohexylmethyl]-8-(tert-butyl-dimethyl-silanyloxy)-6,10,10-trimethyl-1,3-dioxa-spiro[4.5]dec-6-ene

(4S,5S,8S)-4-((1S,2S,6S)-6-tert-Butoxy-2-hydroxymethyl-1-methyl-3-methylene-cyclohexylmethyl)-6,10,10-trimethyl-1,3-dioxa-spiro[4.5]dec-6-en-8-ol

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