(3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Base Information

Chemical Name:(3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate
CAS No.:1018909-83-5
Molecular Formula:C₂₈H₃₉N₃O₅
Molecular Weight:497.635
Hs Code.:

Synonyms:(3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

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Chemical Property of (3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

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Technology Process of (3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

There total 12 articles about (3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1018909-81-3
(3S,4S)-tert-butyl 3-{{6-[benzyl(tert-butoxycarbonyl)amino]-4-methylpyridin-2-yl}methyl}-4-{(1S,4R)-4,7,7-trimethyl-3-oxo-oxabicyclo[2.2.1]heptane-1-carbonyloxy}pyrrolidine-1-carboxylate

: 1018909-83-5
(3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Guidance literature:: With sodium carbonate; In methanol; water; at 20 ℃; for 14h;
DOI:10.1021/ja910228a

Reference yield: 100.0%

: (3S,4S)-tert-butyl 3-{{6'-[benzyl(tert-butoxycarbonyl)amino]-4'-methylpyridin-2'-yl}methyl}-4-{(1S)-4',7',7'-trimethyl-3'-oxo-2'-oxabicyclo[2.2.1]heptane-1'-carbonyloxy}pyrrolidine-1-carboxylate

: 1018909-83-5
(3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Guidance literature:: With water; sodium carbonate; In methanol; at 20 ℃; for 14h;
DOI:10.1021/jm100947x

Reference yield:

: (+/-)-cis-tert-butyl 3-acetoxy-4-{{6'-[benzyl(tert-butoxycarbonyl)-amino]-4'-methylpyridin-2'-yl}methyl}pyrrolidine-1-carboxylate

: 1018909-83-5
(3'S,4'S)-tert-butyl 3'-{{6''-[benzyl(tert-butoxycarbonyl)-amino]-4''-methylpyridin-2''-yl}methyl}-4'-hydroxypyrrolidine-1'carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium carbonate / methanol

2: dmap; triethylamine / dichloromethane

3: water; sodium carbonate / methanol

With dmap; water; sodium carbonate; triethylamine; In methanol; dichloromethane;