4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

Base Information

Chemical Name:4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide
CAS No.:223677-21-2
Molecular Formula:C₂₅H₃₁FN₂O₄
Molecular Weight:442.531
Hs Code.:

Synonyms:4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

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Chemical Property of 4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

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Technology Process of 4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

There total 6 articles about 4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-Benzyloxymethyl-4-ethoxy-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

: 223677-21-2
4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; under 3102.89 Torr;
DOI:10.1016/S0960-894X(98)00716-1

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 223677-21-2
4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃

2: H₂ / 5 percent Rh/C / ethanol / 2585.74 Torr

3: LDA / 0 °C

4: KOH / ethanol / Heating

5: 1-hydroxy-7-azabenzotriazole, 1,3-dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂

6: H₂, HCl / 10 percent Pd/C / ethanol / 3102.89 Torr

With hydrogenchloride; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; Rh on carbon; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00716-1

Reference yield:

: 23676-09-7
ethyl 4-ethoxybenzoate

: 223677-21-2
4-Ethoxy-1-hydroxymethyl-cyclohexanecarboxylic acid [(S)-1-(4-fluoro-phenylcarbamoyl)-2-phenyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 5 percent Rh/C / ethanol / 2585.74 Torr

2: LDA / 0 °C

3: KOH / ethanol / Heating

4: 1-hydroxy-7-azabenzotriazole, 1,3-dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂

5: H₂, HCl / 10 percent Pd/C / ethanol / 3102.89 Torr

With hydrogenchloride; potassium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; Rh on carbon; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00716-1