4-piperidinobutyrophenone hydrochloride

Base Information

• Chemical Name: 4-piperidinobutyrophenone hydrochloride
• CAS No.: 31293-75-1
• Molecular Formula: C₁₅H₂₁NO*ClH
• Molecular Weight: 267.799
• Mol file: 31293-75-1.mol

Synonyms:4-piperidinobutyrophenone hydrochloride

Chemical Property of 4-piperidinobutyrophenone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-piperidinobutyrophenone hydrochloride

There total 1 articles about 4-piperidinobutyrophenone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 4-chloro-1-phenylbutan-1-one (939-52-6) → 4-piperidinobutyrophenone hydrochloride (31293-75-1)

Guidance literature:

With hydrogenchloride; potassium carbonate; Multistep reaction; 1.) acetone, reflux, 48 h;

Reference yield:

4-piperidinobutyrophenone hydrochloride (31293-75-1) → (R)-1-Phenyl-4-piperidin-1-yl-butan-1-ol; hydrochloride + (S)-1-Phenyl-4-piperidin-1-yl-butan-1-ol; hydrochloride

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; triethylamine; (2S,4S)-N-(methylcarbamoyl)-4-(dicyclohexylphosphino)-2-<(diphenylphosphino)methyl>pyrrolidine; In methanol; at 50 ℃; for 72h; under 38000 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1248/cpb.43.748

Reference yield:

4-piperidinobutyrophenone hydrochloride (31293-75-1) → 4-piperidino-butyric acid anilide (4672-15-5) + N-(3-piperidino-propyl)-benzamide (4464-83-9)

Guidance literature:

With sodium azide; sulfuric acid;

DOI:10.1002/hlca.19560390234

upstream raw materials:

piperidine

4-chloro-1-phenylbutan-1-one

Downstream raw materials:

4-piperidino-butyric acid anilide

N-(3-piperidino-propyl)-benzamide

2-Methylene-1-phenyl-4-piperidin-1-yl-butan-1-one; hydrochloride