Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

Base Information

Chemical Name:Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine
CAS No.:107088-99-3
Molecular Formula:C₁₉H₂₀FNO₂
Molecular Weight:313.372
Hs Code.:

Synonyms:Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

Suppliers and Price of Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

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Technology Process of Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

There total 4 articles about Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78495-64-4
(2-fluoro-3,4-dimethoxyphenyl)acetonitrile

: 107088-99-3
Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / KOH / ethanol; H₂O / 20 h / Heating

2: 97 percent / SOCl₂ / toluene / 2.5 h / 100 °C

3: 1.) AlCl₃, 2.) K₂CO₃ / 1.) CH₂Cl₂, 3.5 h, 2.) DMF, 100 deg C, 1.5 h

4: p-toluenesulfonic acid / toluene / 2 h / Heating

With potassium hydroxide; aluminium trichloride; thionyl chloride; potassium carbonate; toluene-4-sulfonic acid; In ethanol; water; toluene;
DOI:10.1021/jm00159a010

Reference yield:

: 78495-65-5
(2-fluoro-3,4-dimethoxyphenyl)acetic acid

: 107088-99-3
Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / SOCl₂ / toluene / 2.5 h / 100 °C

2: 1.) AlCl₃, 2.) K₂CO₃ / 1.) CH₂Cl₂, 3.5 h, 2.) DMF, 100 deg C, 1.5 h

3: p-toluenesulfonic acid / toluene / 2 h / Heating

With aluminium trichloride; thionyl chloride; potassium carbonate; toluene-4-sulfonic acid; In toluene;
DOI:10.1021/jm00159a010

Reference yield:

: 103346-89-0
(2-fluoro-3,4-dimethoxyphenyl)acetyl chloride

: 107088-99-3
Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) AlCl₃, 2.) K₂CO₃ / 1.) CH₂Cl₂, 3.5 h, 2.) DMF, 100 deg C, 1.5 h

2: p-toluenesulfonic acid / toluene / 2 h / Heating

With aluminium trichloride; potassium carbonate; toluene-4-sulfonic acid; In toluene;
DOI:10.1021/jm00159a010