(3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

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Chemical Name:(3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one
CAS No.:314242-44-9
Molecular Formula:C₃₇H₄₈O₅Si
Molecular Weight:600.871
Hs Code.:

Synonyms:(3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

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Chemical Property of (3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

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Technology Process of (3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

There total 20 articles about (3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 314242-24-5
(3aS,4S,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-ol

: 314242-44-9
(3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 0 ℃; for 0.833333h;
DOI:10.1016/S0040-4039(00)01479-9

Reference yield: 81.0%

: C₃₇H₅₀O₅Si

: 314242-44-9
(3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

Guidance literature:: C₃₇H₅₀O₅Si; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 0.75h; Inert atmosphere;
DOI:10.1002/chem.201502113

Reference yield:

: 314242-20-1
(3aS,4S,7aR)-2,2-Dimethyl-3a-prop-2-ynyl-hexahydro-benzo[1,3]dioxol-4-ol

: 314242-44-9
(3aR,7aR)-3a-[(S)-2-Benzyloxy-4-(tert-butyl-diphenyl-silanyloxy)-2-methyl-butyl]-2,2-dimethyl-tetrahydro-benzo[1,3]dioxol-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 92 percent / NaH / dimethylformamide / 2 h / 0 °C

2.1: 97 percent / H₂; quinoline / Lindlar's catalyst / hexane / 1.17 h

3.1: Hg(OAc)2 / methanol / 1 h

3.2: 80 percent / PdCl₂; LiCl; CuCl₂ / 0.5 h

4.1: diethyl ether / -78 °C

5.1: 98 percent / KH; (n-Bu)4NI / dimethylformamide / 1.5 h / 0 °C

6.1: O₃ / methanol / -78 °C

6.2: 78 percent / NaBH₄ / 1 h / 0 °C

7.1: 98 percent / imidazole / dimethylformamide / 0.42 h

8.1: 98 percent / aq. DDQ / CH₂Cl₂ / 0.5 h / 0 °C

9.1: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 - 0 °C

With 1H-imidazole; quinoline; oxalyl dichloride; mercury(II) diacetate; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hydride; sodium hydride; ozone; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Lindlar's catalyst; In methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)01479-9