{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Base Information

Chemical Name:{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester
CAS No.:114504-97-1
Molecular Formula:C₃₀H₄₄Cl₃F₃N₄O₆
Molecular Weight:720.057
Hs Code.:

{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Synonyms:{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

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Chemical Property of {4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

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Technology Process of {4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

There total 6 articles about {4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 874-60-2
4-methyl-benzoyl chloride

: 114491-97-3
[4-(3-tert-Butoxycarbonylamino-propylamino)-butyl]-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

: 114504-97-1
{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 21h;
DOI:10.1021/jo00248a037

Reference yield:

: 90914-14-0
N⁴-Benzyl-N¹-(tert-butoxycarbonyl)spermidine

: 114504-97-1
{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / methanol / 24 h / Ambient temperature

2: 75 percent / NaOH, hydrogen / W-2 Raney nickel / ethanol / 15 h / 2068.6 Torr

3: 82 percent / CH₂Cl₂; benzene / 2 h / 0 °C

4: 86 percent / 0.2 N aq. NaOH / diethyl ether / 0.17 h

5: 60 percent / hydrogen / palladium chloride / acetic acid / 19.5 h / 760 Torr

6: 87 percent / triethylamine / CH₂Cl₂ / 21 h

With sodium hydroxide; hydrogen; triethylamine; W-2 Raney nickel; palladium dichloride; In methanol; diethyl ether; ethanol; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo00248a037

Reference yield:

: 114491-94-0
N¹-(tert-butoxycarbonyl)-N⁴-benzylspermine

: 114504-97-1
{4-[(3-tert-Butoxycarbonylamino-propyl)-(4-methyl-benzoyl)-amino]-butyl}-[3-(2,2,2-trifluoro-acetylamino)-propyl]-carbamic acid 2,2,2-trichloro-1,1-dimethyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / CH₂Cl₂; benzene / 2 h / 0 °C

2: 86 percent / 0.2 N aq. NaOH / diethyl ether / 0.17 h

3: 60 percent / hydrogen / palladium chloride / acetic acid / 19.5 h / 760 Torr

4: 87 percent / triethylamine / CH₂Cl₂ / 21 h

With sodium hydroxide; hydrogen; triethylamine; palladium dichloride; In diethyl ether; dichloromethane; acetic acid; benzene;
DOI:10.1021/jo00248a037