Technology Process of (4S)-1-benzyl-3-<(2S)-2-amino>propionyl>-2-oxoimidazolidine-4-carboxylic acid
There total 12 articles about (4S)-1-benzyl-3-<(2S)-2-amino>propionyl>-2-oxoimidazolidine-4-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium;
In
ethanol;
for 2h;
under 760 Torr;
Ambient temperature;
DOI:10.1021/jm00122a003
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 28percent aq. NH3 / 168 h / Ambient temperature
3: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7
4: SOCl2
5: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
6: ethyl acetate; diisopropyl ether
7: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature
8: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
9: 89.1 percent / H2 / Pd / ethanol / 2 h / 760 Torr / Ambient temperature
With
ammonium hydroxide; thionyl chloride; potassium tert-butylate; hydrogen; potassium carbonate;
palladium;
In
ethanol; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm00122a003
- Guidance literature:
-
Multi-step reaction with 8 steps
2: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7
3: SOCl2
4: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
5: ethyl acetate; diisopropyl ether
6: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature
7: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
8: 89.1 percent / H2 / Pd / ethanol / 2 h / 760 Torr / Ambient temperature
With
thionyl chloride; potassium tert-butylate; hydrogen; potassium carbonate;
palladium;
In
ethanol; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm00122a003